SkinMedica's TNS Advanced Serum features two active formulas that combine to smooth wrinkles and regenerate skin cells for a more youthful appearance. The TNS complex is a protein- and amino acid-rich serum to reduce inflammation and the signs of aging. The APS corrective complex is a mixture of anti-aging ingredients, peptides and antioxidants to strengthen sagging skin. Use this anti-wrinkle serum morning and night after cleansing and toning.